A never before achieved fineness with a centrifugal mill is attained in a short amount of time with the new FRITSCH PULVERISETTE 14 premium line. This became possible because the rotor peripheral speed was increased by more than 20% up to 110m/s, in comparison to instruments to date. A higher fineness is interesting in many aspects: Since many materials change their characteristics and their effects on the organism depending on the particle size, this is interesting for example in the area of exploration of new active components of pharmaceutical products.
For analytical tasks the requirements in regards to homogeneity also increase, since modern analytical instruments need less and less sample material. With a constant initial volume, the analyzed sample amount has to remain representative for the entire sample. This is only possible if the original sample is comminuted further.
Of great interest is also the particle size during extraction as a method of analysis (for example determining the fat content) or as a step in extracting special ingredients for the R & D sector. The specific surface is decisive for the quality and reproducibility of the result. The smaller the particles become, the larger their specific surface gets and much more exact and reproducibly accurate will be the result.
Furthermore is the PULVERISETTE 14 premium line safe like no other instrument on the market. All system- relevant parts like rotor, collection vessel and lid are automatically checked to see if they are complete and if their position is correct before the instrument starts. A faulty operation is therefore impossible. New and unique for this Centrifugal Mill is also the incorporated temperature measurement of the system. Especially during the comminution of heat-sensitive and unstable materials like plastics, resins, plants, spices etc., the milling process can be stopped in time. By changing the accessories, the PULVERISETTE 14 premium line becomes quickly and easily a Cutting Mill. For its variability paired with absolute operator safety, the PULVERISETTE 14 premium line has received an award twice, .
An example from the industry of food and life science impressively shows the difference between established instruments to date (for example the PULVERISETTE 14 classic line) and the PULVERISETTE 14 premium line. With the PULVERISETTE 14 premium line dry mushrooms were comminuted (photo on left) double as fine as it was possible with to date available Centrifugal Mills (see graph). The cell walls of mushrooms contain among other things the so called β-1,3-glucan, which in vitro and in animals based on in-vivo examinations stimulates the immune system and supports et al. the healing of wounds, . Due to a better fine grinding the active component can be extracted more effectively. The familiar cytotoxic effect of β-glucan in the course of cancer treatment is based rather on the impurities of the active component, because if instead of the concentrated, pure β-glucan was used, no cytotoxic effect was detected.
Particle size distribution after comminution with the FRITSCH Variable Speed Rotor Mill PULVERISETTE 14 classic line (orange) and premium line (black). The sample comminuted with the P-14 premium line is twice as fine as the sample ground with the P-14 classic line. For the particle size analysis the Laser Particle Sizer FRITSCH ANALYSETTE 22 NanoTec is utilized.
The above graph shows in comparison the particle size distribution after the comminution of the sample with the PULVERISETTE 14 classic line (20.000 rpm, 0.08 mm sieve ring with trapezoidal perforation, rotor with 24-ribs) and the PULVERISETTE 14 premium line (22.000 rpm, 0.08 mm sieve with ring trapezoidal perforation rotor with 24 ribs). In comparison, to the comminution with the PULVERISETTE 14 classic line the material is double as fine. The d50-value was halved from 26 µm down to 13 µm. The d90-value was also halved (63 µm to 33 µm).
For the comminution of larger amounts into the kilo scale, the PULVERISETTE 14 premium line can be connected with the FRITSCH Vibratory Feeder LABORETTE 24 and with the Cylone Separator. After comminution, the sample is therefore directly and precisely transferred into the collecting vessel. Due to the increased air flow the sample and grinding parts are additionally cooled and the temperature of the system remains constantly below 65°C  – the critical temperature for β-glucan.
 www.orthoknowledge.eu/wissenschaftliche-informationen-uber-beta-glucan-curcumin-zink-vitamin-c/ - ¬(27.07.2016)
 D.A. Przybylska-Diaz, J.G. Schmidt, N.I. Vera-Jiménez, D. Steinhagen, M.E. Nielsen, β-glucan enriched bath directly stimulates the wound healing process in common carp (Cyprinus carpio L.), Fish & Shellfish Immunology, Volume 35, Issue 3, September 2013, Pages 998-1006, dx.doi.org/10.1016/j.fsi.2013.05.014.
 Godfrey Chi-Fung Chan, Wing Keung Chan und Daniel Man-Yuen Sze, The effects of beta-glucan on human immune and cancer cells, Journal of Hematology & Oncology, 2009, Volume 2, pages 1-11, Doi: 10.1186/1756-8722-2-25, dx.doi.org/10.1186/1756-8722-2-25
 www.fritsch.de/aktuell/details/fritsch-gewinnt-best-products-award-waehrend-eurolab/ - (12.08.2016)
 www.chemie.de/news/158510/gleich-zweimal-wurde-die-neue-fritsch-rotor-schnellmuehle-praemiert.html - (12.08.2016)
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